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Bryson compares two factors that limit scientific progress: one that can’t be helped (namely, limitations in technology) and one that can (specifically, dogmatic belief in the superiority of academic enterprises). At this time, scientists are snobbish about contributions that are commercial in focus, and their prejudice slows down progress in chemistry. By contrasting these two factors, Bryson shows that science is already hindered by many things that can’t be helped—like limitations in technology—so it’s especially important for scientists to free themselves of prejudices that can impede scientific progress.