Mother to Mother weaves back and forth in time, covering the narrator, Mandisa’s life from her early childhood, through the birth of her children, through her son, Mxolisi’s murder of the Girl, a white American driving through their township of Guguletu. This is interspersed with The Girl, Mandisa, and Mxolisi’s experiences on the day of the murder, and the morning after.
The novel also includes interludes in which Mandisa addresses the Mother of the Girl, asking rhetorical questions about the Girl’s life and upbringing, expressing her grief for the Girl’s death, and attempting to explain—but not justify—Mxolisi’s actions.
Chronologically, the novel begins with Mandisa’s childhood. She and her brother, Khaya, were raised in Blouvlei, but were forced to relocate to Guguletu by the South African government. This derailed the educations of many students, although Mandisa and Khaya were able to remain in school for a while, at least until Khaya impregnated his girlfriend, Nono, and Mandisa became accidentally pregnant through non-penetrative sex with her boyfriend, China.
Mama, Mandisa’s mother, is furious with her daughter, feeling that her pregnancy will embarrass the whole family, but eventually comes to love Mandisa and her newborn son. Mandisa’s parents force her to marry China, who is no longer interested in her romantically, and the two lived together unhappily for two years, until one day China runs away and disappears forever. Mandisa then moves into a hokkie of her own and does her best to raise Mxolisi, eventually having another child, Lunga, with a man named Lungile, and finally marrying a man, Dwadwa, with whom she has her youngest child and only daughter, Siziwe.
Mandisa recounts Mxolisi’s childhood. A talkative precocious boy, he stops talking for several years after witnessing the death of two older boys, Zazi and Mzamo. He regains his speech, but during his silence Mandisa realizes the resentment she feels for him, for interrupting her life with an unplanned pregnancy, and dramatically changing the course of her future.
As Mxolisi gets older he becomes involved in youth political movements, like the Young Lions. Increasingly radicalized and violent, this group burns cars, buildings, and even kills black South Africans around their township.
On the day of the tragedy, the Girl is driving some of her black South African friends home from their university, when Mxolisi and others spot her in her car. A group of men converge, chasing her from the car, but Mxolisi is the man to stab and kill her. Mandisa discovers this later, spending the first night after the murder anxiously wondering if her son, who has not returned home, was somehow involved. A late night police raid of Mandisa’s house furthers her suspicions.
In the morning, Reverend Mananga stops by and gives Mandisa vague instructions for how to see her son. She follows them and is briefly reunited with Mxolisi, whom she comforts and who comforts her, before he (presumably though not explicitly) turns himself in to the police.
