Survival of the Sickest

by

Sharon Moalem

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Favism is an inherited disorder that affects 400 million people around the world. Favism results in a G6PD enzyme deficiency. The G6PD enzyme is designed to protect the integrity of red blood cells, including by mopping up free radicals (which can be found in fava beans). Free radicals frequently destroy red blood cells, which can in turn result in anemia. However, Moalem illustrates that favism is actually helpful in places in which malaria is prevalent, because the parasite that causes malaria cannot invade damaged red blood cells—like those of people with favism.

Favism Quotes in Survival of the Sickest

The Survival of the Sickest quotes below are all either spoken by Favism or refer to Favism. For each quote, you can also see the other terms and themes related to it (each theme is indicated by its own dot and icon, like this one:
Evolution and Illness Theme Icon
).
Chapter 4 Quotes

By releasing free radicals and raising the level of oxidants, fava bean consumption makes the blood cells of non-G6PD deficient people a less hospitable place for malarial parasites. With all the free radicals, some red blood cells tend to break down. And when someone with a mild or partial deficiency in G6PD eats fava beans, the parasite is in deep trouble.

Related Characters: Sharon Moalem (speaker)
Page Number: 90
Explanation and Analysis:
Conclusion Quotes

I hope that you’ll come away from this book with an appreciation of three things. First, that life is in a constant state of creation. Evolution isn’t over—it’s all around you, changing as we go. Second, that nothing in our world exists in isolation. We—meaning humans and animals and plants and microbes and everything else—are all evolving together. And third, that our relationship with disease is often much more complex than we may have previously realized.

Related Characters: Sharon Moalem (speaker)
Page Number: 207
Explanation and Analysis:
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Survival of the Sickest PDF

Favism Term Timeline in Survival of the Sickest

The timeline below shows where the term Favism appears in Survival of the Sickest. The colored dots and icons indicate which themes are associated with that appearance.
Chapter 4: Hey, Bud, Can You Do Me a Fava?
Interdisciplinary Science and Research Theme Icon
...contained the souls of the dead). Moalem writes that these superstitions were not without merit. Favism is an inherited enzyme deficiency carried by 400 million people—the most common enzyme deficiency in... (full context)
Evolution and Illness Theme Icon
Interspecies Connectivity and Adaptation Theme Icon
This lack of G6PD is known as favism, and it is named that way because when people who have favism eat fava beans,... (full context)
Evolution and Illness Theme Icon
Moalem returns to the connection between fava beans and favism. People who have favism and lack the G6PD enzyme cannot mop up free radicals, which... (full context)
Evolution and Illness Theme Icon
...anemia have better natural resistance to malaria. Today, many scientists believe that a G6PD deficiency (favism) provides even more resistance because the red blood cells are less hospitable to the protozoa,... (full context)
Evolution and Illness Theme Icon
Moalem then explores why the same populations with favism might have cultivated fava beans: he explains that favism is only passed on the X... (full context)