The Double Helix

The Double Helix

by

James D. Watson

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The Double Helix Characters

James D. Watson

The author of The Double Helix is a prominent but controversial Nobel Prize-winning geneticist and molecular biologist. He is still best known for discovering the double helix structure of DNA with Francis Crick. From… read analysis of James D. Watson

Francis Crick

Francis Crick was the prominent, Nobel Prize-winning English molecular biologist and neuroscientist who is best known for discovering the double helix structure of DNA with James Watson in 1953. Watson portrays Crick as talkative, irreverent… read analysis of Francis Crick

Rosalind Franklin

Rosalind Franklin was a pioneering crystallographer and chemist who studied DNA through X-ray diffraction. Her X-ray data enabled Crick and Watson to discover the double helix structure of DNA. However, they obtained this data… read analysis of Rosalind Franklin

Maurice Wilkins

Maurice Wilkins was a Nobel Prize-winning biophysicist who performed important X-ray diffraction experiments on DNA. Wilkins and Rosalind Franklin’s lab at King’s College London was one of three doing this kind of work… read analysis of Maurice Wilkins

Linus Pauling

Linus Pauling was a prominent American chemist, molecular biologist, writer, and activist. He won two Nobel Prizes, one for his scientific research and one for his activism against nuclear proliferation. In the mid-20th century, he… read analysis of Linus Pauling
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Sir Lawrence Bragg

Sir Lawrence Bragg was the internationally renowned, pioneering crystallographer and physicist who ran the Cavendish Laboratory from 1938 to 1953. He won the Nobel Prize in 1915 at just 25 years old, making him by… read analysis of Sir Lawrence Bragg

Erwin Chargaff

Erwin Chargaff was an influential biochemist who conducted many influential early studies on DNA. In fact, he was one of very few scientists who thought DNA—and not proteins—were responsible for heredity before the 1950s… read analysis of Erwin Chargaff

Max Delbrück

Max Delbrück was a prominent biophysicist who frequently collaborated with Salvador Luria on phage research, but also worked alongside Linus Pauling at Caltech in the early 1950s. Because of his connections to both Luria and… read analysis of Max Delbrück

Jerry Donohue

Jerry Donohue was an American chemist and crystallographer who worked in the Cavendish Laboratory. When Watson hypothesized that DNA’s two strands could have the same sequence of nitrogenous bases, Donohue pointed out… read analysis of Jerry Donohue

Herman Kalckar

Herman Kalckar was a prominent Danish biochemist who studied DNA in the early 1950s. Watson’s postdoctoral fellowship was intended to fund him to work in Kalckar’s lab and learn about biochemistry. However, Watson found… read analysis of Herman Kalckar

Peter Pauling

Peter Pauling was a prominent crystallographer and the son of world-renowned chemist Linus Pauling. In 1952, Peter began his PhD research at the Cavendish Lab and quickly befriended James Watson. Their conversations revolved… read analysis of Peter Pauling

Max Perutz

Max Perutz was the influential, Nobel Prize-winning Austrian molecular biologist and crystallographer who ran the Molecular Biology Unit at the Cavendish Laboratory starting in the mid-1940s. As Crick and Watson’s research supervisor, Perutz frequently… read analysis of Max Perutz

Willy Seeds

Willy Seeds was Maurice Wilkins’s research partner at King’s College London. He visited Cambridge to see Crick and Watson’s unsuccessful first model of DNA, and several years after the book’s events, he ran… read analysis of Willy Seeds

Elizabeth Watson

Elizabeth Watson was James Watson’s sister. She frequently visited him throughout his time in Copenhagen and Cambridge—where she stayed during the final months of Crick and Watson’s research into the double helix structure. Watson’s… read analysis of Elizabeth Watson
Minor Characters
John Kendrew
John Kendrew was a Nobel Prize-winning crystallographer and biochemist who was also Max Perutz’s main research partner at the Cavendish Laboratory. He was one of Watson’s most important mentors at Cambridge. In fact, Watson lived with Kendrew and his wife Elizabeth throughout his time there.
Salvador Luria
Salvador Luria was the Nobel Prize-winning microbiologist and phage researcher who supervised Watson’s thesis. During Watson’s time in Europe, Luria helped him find research funding and connect with other scientists. The U.S. government also banned him from international travel for his peace activism.
J.D. Bernal and I. Fankuchen
Bernal and Fankuchen were crystallographers who conducted important X-ray diffraction experiments on tobacco mosaic virus (TMV).
Odile Crick
Odile Crick was Francis Crick’s wife and an internationally renowned artist. Watson portrays her as loving, conventional, and ignorant about science—but also suggests that this is how scientists’ wives ought to be.
Bill Cochran
Bill Cochran was a Scottish crystallographer who worked at the Cavendish Laboratory. He and Francis Crick developed an innovative new method to study helical molecules through X-ray diffraction. This method helped Crick and Watson interpret Rosalind Franklin’s X-ray data and identify that DNA is helical.
Bertrand Fourcade
Bertrand Fourcade was an attractive, popular French exchange student who dated Watson’s sister Elizabeth.
R.G. Gosling
Raymond George (R.G.) Gosling was a graduate student who worked under Rosalind Franklin in the lab that she and Maurice Wilkins shared at King’s College London.
John Griffith
John Griffith was a theoretical chemist and friend of Francis Crick at Cambridge. His calculations showed Crick and Watson that adenine could bond with thymine and guanine could bond with cytosine.
Bill Hayes
Bill Hayes was an Irish geneticist who studied bacterial mating during Watson and Crick’s time at Cambridge.
Dorothy Hodgkin
Dorothy Hodgkin was a Nobel Prize-winning chemist and pioneering crystallographer at Oxford.
Hugh Huxley
Hugh Huxley was Francis Crick’s close friend and John Kendrew’s graduate student. He studied muscle fibers and taught Watson how to do X-ray diffraction experiments.
Ole Maaløe
Ole Maaløe was a Danish phage researcher with whom Watson worked extensively during his time in Copenhagen (although he was supposed to be working under Herman Kalckar instead).
Roy Markham
Roy Markham was a biochemist at Cambridge who specialized in studying plant viruses. He helped Watson get his fellowship transferred to Cambridge and supervised some of Watson’s work on TMV.
Avrion Mitchison
Avrion Mitchison was one of Crick and Watson’s friends at Cambridge. He invited Watson to his family home in Scotland one Christmas. In fact, a decade later, Watson also wrote most of this book at Mitchison’s house.