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In Chapter 48, when Sikes attempts to escape after killing Nancy, an allusion to Shakespeare's Macbeth heightens the stakes of Sikes's situation:
Up and down the ladders, upon the roofs of buildings, over floors that quaked and trembled with his weight, to under the lee of falling bricks and stones,—in every part of that great fire was he; but he bore a charmed life, and had neither scratch nor bruise, nor weariness nor thought, till morning dawned again, and only smoke and blackened ruins remained.
In Shakespeare's play, Macbeth launches a murder spree in pursuit of power, in part because he has heard a prophecy that convinces him that he can't be killed by anyone who has been birthed by a woman. When Macduff pursues him to bring him to justice, Macbeth tells him, "I bear a charmed life, which must not yield / To one of woman born." Unfortunately for him, it turns out that Macduff was not "born" in the traditional way, but rather through a cesarean section, so Macduff is able to kill him after all. This allusion makes clear that Sikes's "charmed life" is merely prolonging his death, as it does for Macbeth. In other words, the end is coming for him.
By evoking Macbeth, the novel suggests that villains' obsession with power is a pursuit that will ultimately result in their demise, both physically and psychologically. Sikes not only dies for his crime, but he also evidences the same kind of paranoia over the blood he has spilled as Lady Macbeth famously exhibits when she can't seem to wash all the blood of murder off her hands. Like Macbeth, Sikes eventually dies for the murder he has committed. But his death is a self-inflicted accident that happens in the course of his flight from the people who are trying to hold him accountable. Like Lady Macbeth, Sikes dies at his own hand after losing his mind from guilt and paranoia. The reader is left understanding that Fagin, who manipulated Sikes into killing Nancy, is the real Macbeth character. He maintains his criminal fiefdom by recruiting others to commit crime and even murder on his behalf. Macbeth famously describes life as "a tale / Told by an idiot, full of sound and fury, / Signifying nothing." In the end, Sikes, Nancy, the Artful Dodger, and other criminals seem to lead lives that "signify nothing." Of Fagin's crew, only Oliver maintains the possibility of a meaningful life because he resists manipulation by Fagin.

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Common Core-aligned